Neurocardiac Autonomic Dysfunction in Patients With Post-COVID-19 Condition: A Systematic Review and Meta-Analysis.

Eur J Neurol · 2026 · PMC13093672 · PMID 41814525

Europe PMC DOI

hedged sentences

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closest p · 1.6× alpha

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boldest claim

The sentences

did not reach statistical significancep = 0.08so close (0.05 < p ≤ 0.1)

The meta‐analysis revealed a trend toward reduced SDNN in individuals with post‐COVID condition compared to healthy controls, with a small to moderate effect size that did not reach statistical significance (Standardised Mean Difference [SMD] 0.2642, 95% confidence interval [CI]: −0.0361 to 0.5644; p = 0.08).

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a possible trendno p-value reported

Discussion Our systematic review and meta‐analysis suggest a possible trend between post‐COVID condition and alterations in neurocardiac autonomic function, characterised by a trend toward decreased HRV.

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