Flow orientation as a critical parameter in nanoscale membrane filtration for optimising small extracellular vesicle isolation.

The simulation showed a trend of decreasing percentage filtration with decreasing angle size ( Fig. 1e ), which was also reflected experimentally ( Fig. 3g ) with F90 having the most concentrated filtrate (23%) and a gradual percentage filtration decrease to F60 (13%) and F30 (9%).

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