highly significantP < 0.0001
From 1999 to 2015, there was a statistically significant rise in mortality (APC = 6.30; 95% CI, 4.08 to 7.67; P = 0.0036), followed by an even steeper and highly significant increase from 2015 to 2023 (APC = 15.87; 95% CI, 11.85 to 24.98; P < 0.0001), representing the most pronounced regional acceleration in mortality.