Multi-omics analysis of patient-derived organoids reveals that E3 ligase COP1 promotes liver metastasis and oxaliplatin resistance in colorectal cancer through LUZP1 degradation and MYL9 phosphorylation.

Exp Hematol Oncol · 2026 · PMC13094177 · PMID 41937206

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did not reach statistical significanceno p-value reported

Compared with the PR group, patients in the PD group tended to have higher T/N staging and showed a greater proportion of lymphovascular invasion, perineural invasion and KRAS mutation, although these differences did not reach statistical significance.

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