Tryptophan Indole Metabolites Reduce Anastomotic Leakage Through Aryl Hydrocarbon Receptor-Driven Interleukin-22 Production.

Cell Mol Gastroenterol Hepatol · 2026 · PMC13094658 · PMID 41707749

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0.0600

closest p · 1.2× alpha

0.0600

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showed a trendP = .06so close (0.05 < p ≤ 0.1)

Analysis showed a trend towards higher levels of indole-3-acetic acid (IAA), a known AhR agonist 14 , 16 in patients with AH vs AL ( P = .06) ( Supplementary Table 2 ), but no difference in the other metabolites related to the indole, kynurenine (indoleamine 2,3-dioxygenase [IDO]), or serotonin (5-hydroxytryptamine [5-HT]) pathway or in Trp itself ( Supplementary Table 2 ) between patients with AL and AH.

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