Semaglutide Effects on Insulin Sensitivity and β-Cell Function in Patients With Schizophrenia, Prediabetes, and Obesity Treated With Second-Generation Antipsychotics: Findings From the HISTORI Trial, a 30-Week Randomized, Placebo-Controlled Trial With Semaglutide 1.0 mg Weekly.

Diabetes Care · 2026 · PMC13094869 · PMID 41778920

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did not reach statistical significanceno p-value reported

We were also able to demonstrate that the semaglutide-treated group, alongside the reduction in HbA 1c , showed improvements in fasting blood glucose, while its effects on fasting C-peptide and insulin levels did not reach statistical significance.

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