Endoplasmic reticulum stress at the forefront of fatty liver diseases and cancer.

Pharmacol Rev · 2025 · PMC13095497 · PMID 41197470

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did not reach statistical significanceno p-value reported

204 The pegbelfermin group showed reductions in LFF and some improvements in inflammation, but the effects on fibrosis regression and MASH resolution did not reach statistical significance. 204 Notably, a parallel trial tested efruxifermin in patients whose liver conditions were similar to those in FALCON2 (F4 fibrosis and compensated cirrhosis).

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