SirT2 Inhibition is Associated with Improvements in Depression-like Behavior and Memory Impairment in Olfactory Bulbectomized Mice.

Mol Neurobiol · 2026 · PMC13095938 · PMID 42010199

Europe PMC DOI

hedged sentence

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

a decreasing trendp = 0.06so close (0.05 < p ≤ 0.1)

did not reach statistical significancep = 0.06so close (0.05 < p ≤ 0.1)

In contrast, the expression level of arginase-1, an M2-type microglial marker, was significantly reduced in OBX mice, while TGF-β exhibited a decreasing trend that did not reach statistical significance ( p = 0.06; Fig. 4 J and K).

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