CIDEC impairs mitochondrial fitness and blocks protective autophagy via the inhibition of cGMP/PKG pathway to exert tumor-suppressive effects in breast cancer.

Cell Oncol (Dordr) · 2026 · PMC13096410 · PMID 42010152

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did not reach statistical significanceno p-value reported

It is noteworthy that the decreases in MFN2, OPA1, and DRP1 levels showed significant differences relative to the oe-CIDEC + 8-Br-cGMP group, whereas the downregulation of MFN1 expression did not reach statistical significance.

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