Apolipoprotein E Deficiency Impairs Human Microglial Proliferation Accompanied by Elevated Cellular Oxidative Stress.

Although these transcriptional shifts did not reach statistical significance, the pattern was reproducible across independent replicates and suggested a coordinated attenuation of lipid catabolic programmes accompanied by partial activation of cholesterol storage genes, indicative of altered lipid handling in APOE −/− iMGLs.

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