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JAK Inhibitors for Crohn's Disease: A Systematic Review and Dose-Response Network Meta-Analysis of Efficacy and Safety.

JGH Open · 2026 · PMC13097650 · PMID 42022940

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Upadacitinib 6 mg BID showed the highest relative efficacy (RR: 2.7, 95% CrI: 0.69–11.0), followed by 24 mg BID (RR: 2.2, 95% CrI: 0.56–9.5), but these differences did not reach statistical significance (Figure 3 ).

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