Non-linear associations of amyloid-β with resting-state functional networks and their cognitive relevance in a large community-based cohort of cognitively normal older adults.

RCFT delayed recall showed similar associations in the precuneus ( β = 0.147, 95% CI: 0.078–0.216, Δ R 2 = 0.021, P = 0.001, FDR corrected), dorsal DMN ( β = 0.147, 95% CI: 0.078–0.216, Δ R 2 = 0.021, P = 0.001, FDR corrected), and posterior salience ( β = 0.120, 95% CI: 0.052–0.188, Δ R 2 = 0.014, P = 0.012, FDR corrected) networks, with a trend toward significance for ventral DMN ( β = 0.093, 95% CI: 0.025–0.161, Δ R 2 = 0.009, P = 0.069, FDR corrected).

also in 2,517 other papers

In the ventral DMN, the quadratic Aβ term remained significant ( β = -0.083, 95% CI: -0.139 to -0.028, P = 0.024, FDR-corrected), whereas the linear term was not ( β = 0.061, 95% CI: -0.016–0.139, P = 0.522, FDR-corrected), and the combined Aβ terms showed a trend-level improvement in model fit (Δ R 2 = 0.009, P = 0.094, FDR-corrected).

also in 33,481 other papers