Enhanced Whitening Effect of the Formulations via Inhibition of Tyrosinase Activity by Combination of 4-n-Butylresorcinol, Licochalcone A and Glabridin at an Optimal Ratio.

When treated with 5 g/L skin whitening formula with 577 PRO (in which 577 PRO is only below 1%), the melanin production inhibition effect is also quite significant with an inhibition rate of 47%, which proved that the formula with 577 PRO can effectively inhibit the melanogenesis in the zebra fish model (Figure 3c ). 4.4 3D Melanin Skin Model (MelaKutis) Test Under UVB Irradiation Before using in human skin efficacy test, we detected UVB‐induced melanogenesis with or without skin whitening formula with 577 PRO, and further evaluated its inhibition of melanogenesis effect at the histological level in the 3D melanin skin model under UVB irradiation.

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