An exploratory Mendelian randomization study on the genetically predicted effects of circulating blood cells on osteoarthritis risk.

Clinics (Sao Paulo) · 2026 · PMC13098457 · PMID 42000535

Europe PMC DOI

hedged sentences

0.0750

closest p · 1.5× alpha

0.0750

boldest claim

The sentences

did not reach statistical significancep = 0.075so close (0.05 < p ≤ 0.1)

However, it is crucial to note that while the IVW method yielded a significant result, the MR-PRESSO outlier-corrected estimate ( Table 2 ) did not reach statistical significance (p = 0.075), suggesting that the IVW result may be driven by horizontal pleiotropy or outliers.

also in 111,027 other papers

borderline significanceno p-value reported

The borderline significance of the main findings highlights the risk of false positives inherent in such an approach.

also in 7,017 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.