The influence of murine cytomegalovirus infection on susceptibility to mycobacterial infection.

3 , 8 , 9 , 10 Several cohort and case-control studies have suggested that CMV infection during the first few months of life was associated with an increased risk of TB disease during follow-up and showed a trend toward a higher prevalence of Mtb infection following CMV infection. 11 , 12 , 13 CMV-specific IgG levels in the blood have also been reported to be correlated with an increased risk of TB disease in adults. 14 , 15 A comprehensive review has highlighted the complexity of the epidemiological and immunological relationship between CMV and TB; however, the mechanisms that account for the increased susceptibility to TB in CMV-infected individuals are less well understood. 16 CMV has strict species specificity.

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