The Effects of Conservative Fluid Management and Active Deresuscitation on Markers of Tissue Perfusion, Kidney Injury, and Vascular Injury in Critically Ill Adults: A Secondary Analysis of the Role of Active Deresuscitation After Resuscitation-2 (RADAR-2) Trial.

Crit Care Explor · 2026 · PMC13098782 · PMID 42010883

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did not reach statistical significanceno p-value reported

For each of high hyaluronan (aOR, 2.80; 95% CI, 0.32–24.81; p = 0.36), high syndecan-1 (aOR, 1.06; 95% CI, 0.13–8.46; p = 0.96), or high NT-proBNP (aOR, 0.29; 95% CI, 0.01–7.79; p = 0.46), testing for an interaction between biomarker and treatment allocation did not reach statistical significance ( Fig.

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