A kappa opioid receptor agonist, difelikefalin, improves acute kidney injury in experimental sepsis models.

PLoS One · 2026 · PMC13098930 · PMID 42013153

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We also detected kappa opioid receptors in renal medullary interstitial cells, and stimulation of these receptors in isolated renal interstitial cells showed a trend to attenuate cytokine expression.

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