At lower MOIs, IFNβ expression increased, consistent with reduced antagonism, and IFNβ transcripts showed a trend of increasing in HeV-g2-infected cells compared with HeV-g1-infected cells, with a statistically significant difference observed at an MOI of 2 ( Fig. 6 ).
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Hendra virus genotypes 1 and 2 differ in V protein-mediated immune evasion.
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These data reveal differences in the fundamental biology of HeV genotypes, which may be significant to pathogenesis.