Pharmacological interventions to improve bone density in functional hypothalamic amenorrhea: a systematic review and network meta-analysis of randomized clinical trials.

J Clin Endocrinol Metab · 2026 · PMC13099214 · PMID 41505334

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did not reach statistical significanceno p-value reported

Although the study demonstrated a 43% lower incidence of stress fractures among COCP users, this difference did not reach statistical significance, likely due to limited statistical power ( 34 ).

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