Identifying treatment response classes to transcranial direct current stimulation from daily ecological momentary assessment patterns in patients with depression.

37 Also, in the current study, this cluster showed the highest V1 scores across clusters on items indicating melancholic profiles such as BDI-4 (loss of pleasure; 2.21 ± 0.93 vs 1.88 ± 0.76 in Cluster 0 and 1.90 ± 0.88 in Cluster 2), MADRS-8 (inability to feel; 3.12 ± 1.49 vs 2.87 ± 1.53 in Cluster 0 and 2.50 ± 1.65 in Cluster 2), and MADRS-1 (apparent sadness; 3.27 ± 1.01 vs 2.85 ± 1.11 in Cluster 0 and 2.70 ± 1.16 in Cluster 2), although most between-cluster differences did not reach statistical significance with the exception of BDI-4 ( P = .047).

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There were no significant differences across clusters in any covariates, including demographic characteristics, tDCS-related factors, or mental/physical health factors, although years of education and comorbid mental disorders exhibited marginally significant differences between clusters ( Table 1 ).

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