Aberrant expression of long non-coding RNAs and their regulatory role in chromatin-mediated gene expression changes in the prefrontal cortex of major depressive disorder subjects.

Mol Psychiatry · 2026 · PMC13099372 · PMID 41413201

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

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boldest claim

The sentences

very close to significancep = 0.06so close (0.05 < p ≤ 0.1)

Following Spearman’s method, an inverse correlation (R = −0.39) between the 60 lncRNAs and the 24 coding genes was observed in the MDD group, which was very close to significance (p = 0.06) (Fig. 5E ).

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did not reach statistical significanceno p-value reported

However, this association did not reach statistical significance, and the inverse pattern is subtle in the scatter plot (Fig. 5E ).

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