Solid tumour CAR-T cells engineered with fusion proteins targeting PD-L1 for localized IL-12 delivery.

Nat Biomed Eng · 2026 · PMC13099387 · PMID 41034514

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showed a trendno p-value reported

Analysis of blood plasma collected from mice showed a trend of higher systemic inflammation with higher IFNγ in TAG72–CAR/αPD-L1 mut –IL-12 relative to TAG72–CAR/αPD-L1–IL-12 T cell treatment (Fig. 3g , left), similar to our in vivo prostate model observations.

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