Domain-general demands that deactivate multiple-demand regions.

Combined across all MD ROIs, a Bayesian repeated-measures ANOVA examining the difference between the two phases (beginning and main episode) in the effect of difficulty (hard–easy) was highly significant (BF incl = 10 6 ).

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The differential effect of difficulty at the beginning versus during the execution of the episode failed to reach significance at the whole-brain level with repeated-measures ANOVA when corrected for multiple comparisons using the false discovery rate ( Fig. 6 ).

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While the onset of hard episodes did not result in widespread deactivation (unlike experiment 1), key MD regions (preSMA, IPS) showed a trend toward deactivation.

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