The serotonin 1B receptor is required for some of the behavioral effects of psilocybin in mice.

Mol Psychiatry · 2026 · PMC13099419 · PMID 41422160

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hedged sentences

0.0810

closest p · 1.6× alpha

0.1100

boldest claim

The sentences

did not reach statistical significancep = 0.081so close (0.05 < p ≤ 0.1)

Though the interaction of genotype and treatment did not reach statistical significance (F(2, 384) = 2.53, p = 0.081), because there were baseline differences, we compared the effect of psilocybin within each genotype.

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trending toward significancep = 0.11not close (p > 0.1)

Though the interpretation of this result is limited by an effect in controls that was only trending toward significance (t12 = 1.461, p = 0.11), a lack of effect in the adult knockdown suggests that any developmental compensation was likely not responsible for the lack of effects seen in the whole-brain whole-life knockouts.

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