Modulation of Oxidative Stress and Apoptosis by Antrodia cinnamomea-Loaded Citrate-Stabilized Silver Nanoparticles in Experimental Parkinsonism.

The observation that dopamine and acetylcholine levels were comparable or showed an increasing trend in the control, AC, AgNPs, and AC + AgNPs groups indicates that these treatments did not exert toxic effects on the dopaminergic or cholinergic systems; rather, they may play a modulatory role.

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TH immunoreactivity was significantly increased in the L-DOPA + 6-OHDA and AC + AgNP + 6-OHDA groups compared with the 6-OHDA group, whereas the increases observed in the AC + 6-OHDA and AgNP + 6-OHDA groups did not reach statistical significance (Fig. 4 D).

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