7 Conversely, in a CRCT of a Vi polysaccharide vaccine in Kolkata, this approach demonstrated higher total and overall protection in the innermost subclusters and significant indirect protection for the entire cluster but failed to show a clear trend for indirect protection due to limited sample size. 8 These findings highlight the challenges of detecting herd protection, or its limited presence in densely populated urban settings where transmission dynamics are complex, although it has been observed, as demonstrated by the study in Kolkata.
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The association between vaccine coverage and herd protection: exploratory analyses of a cluster-randomised trial of Vi conjugate vaccine.
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