Differential metabolic responses to hydrogen peroxide-induced oxidative stress in parotid and submandibular gland acinar cell lines.

However, due to high biological variation observed between replicates in the PG cell line, these elevations did not reach statistical significance. α-Ketoglutaric acid, a precursor of succinic acid in the TCA cycle, exhibited a decreasing in both PG and SMG acinar cells under 150 μM H 2 O 2 treatment compared to the control, although the change was not statistically significant.

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In contrast, PG cells displayed an increasing trend in these metabolites.

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