Efficacy and safety of immune checkpoint inhibitors in patients with high microsatellite instability/mismatch repair-deficient advanced cholangiocarcinoma: A propensity score-matched study.

JHEP Rep · 2026 · PMC13101787 · PMID 41996832

Europe PMC DOI

hedged sentence

0.2210

closest p · 4.4× alpha

0.2210

boldest claim

The sentences

did not reach statistical significancep = 0.221not close (p > 0.1)

Although PD-L1 positivity was associated with numerically favorable OS and PFS, the associations did not reach statistical significance in multivariable Cox analyses (OS: adjusted HR 0.70, p = 0.221; PFS: adjusted HR 0.61, p = 0.063).

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