Prolonged KRAS-MAPK Inhibition Induces Interferon Signaling That Promotes Cell State Transition and Confers Therapeutic Vulnerabilities.

Cancer Res · 2026 · PMC13101933 · PMID 42008116

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hedged sentence

0.1300

closest p · 2.6× alpha

0.1300

boldest claim

The sentences

showed a trendP = 0.13not close (p > 0.1)

From bulk RNA-seq of PDAC samples, TRIM22 showed a trend of being upregulated ( P = 0.13 ), whereas HIST1H3B was significantly downregulated ( P = 0.0009 ) in ulixertinib-treated cohorts (Supplementary Fig.

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