From Supplements to Sight: Quantifying the Impact of Lutein and Carotenoid on Age-Related Macular Degeneration-A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

J Ophthalmol · 2026 · PMC13101954 · PMID 42028334

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hedged sentence

0.2910

closest p · 5.8× alpha

0.2910

boldest claim

The sentences

did not reach statistical significancep = 0.291not close (p > 0.1)

By comparison, combination formulations (lutein plus zeaxanthin or epilutein) showed a significant benefit for MPOD (Hedges’ g = −0.551; p = 0.029), whereas the effect on BCVA did not reach statistical significance (Hedges’ g = −0.484; p = 0.291) (Supporting Figure S1 ). 3.4.

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