Reversible and causal epigenetic information loss in liver aging and disease.

PNAS Nexus · 2026 · PMC13101997 · PMID 42028154

Europe PMC DOI

hedged sentences

0.0001

closest p · 0.0× alpha

0.1700

boldest claim

The sentences

highly significantP = 0.0001actually significant

The enrichment was highly significant compared to random control regions ( P = 0.0001) and decreased with distance from the genetic variants ( Supplementary Dataset S4 ).

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did not reach statistical significanceP = 0.17not close (p > 0.1)

Testing the directionality of the change, in the damaging category, in Aging-GIP1, 85% of sites have negative beta values ( P = 0.006), while Longevity-90th had 70% negative beta values, but did not reach statistical significance ( P = 0.17), possibly due to the low sample size ( N = 10).

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