A quantitative in vivo CRISPR-imaging platform identifies regulators of hyperplastic and hypertrophic adipose morphology in zebrafish.

Three additional genes showed nominally significant effects in pooled KS tests prior to false discovery rate (FDR) correction but were not validated by stratified within-experiment analysis: ptprdb (hypertrophic, +18.5%), ptenb (hyperplastic, −7.9%), and srpx (hyperplastic, −0.9%) ( Table 1 ).

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With this normalisation, foxp1b single mutants show only a non-significant trend toward decreased adiposity (updated from our original analysis), while the hypertrophic LD morphology remains highly significant - demonstrating the phenotype is independent of body size and not a developmental delay. - Revised title.

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