Presynaptic chloride-dependent regulation of spontaneous glutamate release in the rat medial preoptic nucleus.

Front Cell Neurosci · 2026 · PMC13102574 · PMID 42038341

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hedged sentences

0.0003

closest p · 0.0× alpha

0.0780

boldest claim

The sentences

highly significantp = 2.93 × 10 −4actually significant

A paired Wilcoxon signed-rank test confirmed a highly significant reduction ( W = 0, p = 2.93 × 10 −4 : n = 18, N = 14), with a very large effect size ( r = 0.88).

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did not reach statistical significancep = 0.078so close (0.05 < p ≤ 0.1)

Although the baseline frequency of mEPSCs was lower under these conditions (0.60 ± 0.14 Hz, median 0.52 Hz; 95% CI 0.35 to 0.86 Hz) compared with the preceding sEPSC frequency in control (0.82 ± 0.20 Hz, median 0.64 Hz; 95% CI 0.49 to 1.24 Hz), this reduction did not reach statistical significance (Wilcoxon W = 3, p = 0.078; n = 7, N = 5).

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