Follicular fluid SCUBE1 as a novel angiogenesis-associated biomarker in women undergoing ART: a pilot study reflecting the follicular vascular microenvironment.

J Assist Reprod Genet · 2026 · PMC13103049 · PMID 41588214

Europe PMC DOI

hedged sentences

0.0320

closest p · 0.6× alpha

0.0870

boldest claim

The sentences

a positive trendp = 0.032actually significant

When the ordinal increasing trend among groups was evaluated using the Jonckheere-Terpstra Trend Test, a statistically significant upward trend in FF SCUBE1 levels was detected as the oocyte yield groups increased (Standardized J-T Statistic = 2.145, p = 0.032, indicating a positive trend).

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borderline significancep = 0.087so close (0.05 < p ≤ 0.1)

Fifth, the relatively small sample size in the high responder group ( n = 10) likely contributed to the borderline significance ( p = 0.087) of SCUBE1 in the multivariate model, underscoring the need for validation in larger cohorts.

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nominally significantno p-value reported

While Bonferroni correction was calculated ( p < 0.017), p -values < 0.05 were considered nominally significant for exploratory biomarker analysis to avoid Type II errors in this pilot cohort.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.