Polyphenol mediated zinc-oxygen synergistic hydrogel remodels senescent microenvironment for periodontal tissue regeneration.

Nat Commun · 2026 · PMC13103323 · PMID 41803114

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did not reach statistical significanceno p-value reported

Lactobacillus , which exerts a probiotic effect in PD through the competitive rejection of pathogenic bacteria and has a positive immunomodulatory effect 38 , increased in the PD+Mn-hCaO 2 /hZIF8/SMA group, though this effect did not reach statistical significance (Fig. 7F ).

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highly significantno p-value reported

These results revealed that the Mn-hCaO 2 /hZIF8/SMA hydrogel can modulate the M1/M2 ratio, which in turn can produce highly significant changes in the cytokine network in the niche and steer the environment towards a pro-regenerative state.

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