Functional analyses identify the L1 ORF2p Cryptic domain as a hub for intramolecular interfaces required for retrotransposition.

Nucleic Acids Res · 2026 · PMC13103738 · PMID 42023654

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did not reach statistical significanceno p-value reported

The interaction of the other two Cryptic variants with the EN domain trended lower than the wildtype but did not reach statistical significance.

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