Astrocytic TIA1-Mediated Stress Granules Promote the Demyelination of Optic Neuritis by Sequestering mRNA of Cholesterol Synthesis Genes in an Experimental Autoimmune Encephalomyelitis Model.

qRT‐PCR analysis further confirmed the up‐regulation of the mRNA level of HMGCS1, HMGCR, LDLR , and FDPS in Tia1 Nestin ‐CKO EAE mice, while SQLE showed an upward trend that did not reach statistical significance (Figure 5D–H ).

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