Cardiac safety profiles of first-generation vs second-generation BTK inhibitors: a meta-analysis.

Oncologist · 2026 · PMC13105294 · PMID 41871445

Europe PMC DOI

hedged sentence

0.1750

closest p · 3.5× alpha

0.1750

boldest claim

The sentences

did not reach statistical significanceP = .175not close (p > 0.1)

Notably, although ibrutinib was associated with a numerically higher odds of ventricular tachycardia compared to second-generation agents, this difference did not reach statistical significance (OR 1.97, 95% CI 0.74-5.22; P = .175), likely reflecting limited statistical power due to the low incidence of this outcome across included studies.

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