Analysis of plasma exosomal differential proteins and bioinformatics in intrahepatic cholestasis of pregnancy.

In addition, we also explored the common DEPs from different groups, from the Venn plot of T-EXO, we found that the protein PIGR ( P01833 ) was identified as a DEP in all groups, and the expression of this protein showed an increasing trend from the onset of the disease to the progression of the disease to the severity, suggesting that this protein may be an important protein for disease progression ( Supplementary Figure S1O and Table S6 ).

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Supervised PLS-DA analysis showed a clear trend of separation between the ICP and CTR groups, which were able to be completely differentiated ( Figure 2E ). 200 permutation tests confirmed that the model was robust with no overfitting (R2 = 0.809, Q2 = 0.064) ( Figure 2F ).

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