CD4<sup>+</sup> and CD8<sup>+</sup> T cells contribute to psoriasis phenotype when integrated into human skin equivalents for drug testing.

Front Immunol · 2026 · PMC13106556 · PMID 42039187

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did not reach statistical significanceno p-value reported

While cytokine suppression (IFN-γ, TNF-α, IL-17A) did not reach statistical significance due to inter-donor variability, consistent downward trends were observed in most CD4 + T cell–containing cultures.

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CD4&lt;sup&gt;+&lt;/sup&gt; and CD8&lt;sup&gt;+&lt;/sup&gt; T cells contribute to psoriasis phenotype when integrated into human skin equivalents for drug testing.

The sentences

CD4<sup>+</sup> and CD8<sup>+</sup> T cells contribute to psoriasis phenotype when integrated into human skin equivalents for drug testing.