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Vitamin D Receptor Polymorphisms and the Effect of Vitamin D Supplementation on Diabetes Risk Among Adults With Prediabetes.

JAMA Netw Open · 2026 · PMC13107228 · PMID 42024385

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2 Although the primary outcome did not reach statistical significance in the intent-to-treat analysis (hazard ratio [HR], 0.88 [95% CI, 0.75-1.04]), further analyses revealed that the effect of vitamin D 3 depended on the achieved intratrial serum 25-hydroxyvitamin D (25[OH]D) levels.

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