Locus coeruleus degeneration is associated with cortical tau deposition and cognitive decline in older adults at familial risk of Alzheimer's disease.

Alzheimers Dement · 2026 · PMC13108248 · PMID 42029407

Europe PMC DOI

hedged sentence

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

did not reach statistical significancep = 0.06so close (0.05 < p ≤ 0.1)

The association between ΔLC RI and cognitive decline appeared slightly stronger among people with higher global Aβ, but this did not reach statistical significance (time × ΔLC RI × Aβ interaction: β = 0.05, CI [0.00 to 0.10], t 1236 = 1.87, p = 0.06).

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