Third, the sample size ( n = 22 total, 11 per group) was relatively small and may have been inadequate to detect statistically significant differences in some outcomes, particularly the CBVI, where a trend toward significance ( P = 0.073) was observed, and would likely have reached statistical significance with a larger sample size.
Although this difference did not reach statistical significance, likely due to the limited sample size, the trend favored greater intravascular volume with slower infusion rates.
Baseline-adjusted mean central blood volumes over the four measurements were greater in the slow IVF versus fast group; however, the difference fell short of statistical significance ( P = 0.073), indicating a nonsignificant trend toward greater central blood volume with slower infusion.