Completion of perioperative chemotherapy and tumor regression grade as independent predictors of one-year survival after total gastrectomy for gastric cancer: a retrospective cohort study.

This survival advantage remained highly significant in the 60-day landmark analysis ( p = 0.004).

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Furthermore, while the occurrence of severe postoperative complications (Clavien-Dindo ≥ III) was prevalent across the cohort, their inclusion in the multivariable model demonstrated a trend toward increased mortality that did not reach statistical significance (HR = 1.67, 95% CI 0.86–3.23, p = 0.130) and did not diminish the strong, independent survival benefit associated with completing the perioperative treatment sequence.

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