Parallel Single-Tissue Summary-Data Mendelian Randomization and Functional Validation Identify the ARRDC1 Promoter SNP rs4494021 as a Genetic Marker Associated with Anxiety Disorders.

Neuropsychiatr Dis Treat · 2026 · PMC13110040 · PMID 42038593

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did not reach statistical significanceno p-value reported

Other parameters (total distance: unadjusted p = 0.0082; time spent in center: unadjusted p = 0.0327; entries into the open arms: unadjusted p = 0.0376; light–dark transitions: unadjusted p = 0.0086) showed consistent directional trends but did not reach statistical significance after correction ( Figure 9 ).

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