Fair and Square: Design, Synthesis and Biological Evaluations of Squaric Acid Derivatives as Novel HDAC8 Inhibitors.

ChemMedChem · 2026 · PMC13110267 · PMID 42035225

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a clear trendno p-value reported

3 Discussion The SAR observed across the four subfamilies reveals a clear trend governing HDAC8 inhibition by squaric acid‐derived analogues.

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