Elevated serum brain injury markers are associated with disease activity, pro-inflammatory cytokine levels and cognitive dysfunction in adolescents with childhood-onset SLE.

Higher Tau levels correlated with higher SLEDAI-2K at study visit (r=0.40, p=0.002) and AMS over the disease duration (r=0.49, p=0.002), although these did not reach statistical significance for a corrected p value <0.002.

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