Mechanism-based management of taxane-induced neuropathic pain in breast cancer survivors: a critical review.

Front Pain Res (Lausanne) · 2026 · PMC13111207 · PMID 42052302

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.2040

boldest claim

The sentences

a statistical trendp = 0.06so close (0.05 < p ≤ 0.1)

There was a statistical trend toward smaller dose reductions in the IE group ( p = 0.06), and significantly more patients in the IE group reached the ≥ 85% threshold for relative dose intensity (RDI) ( p < 0.005), suggesting that exercise may support the maintenance of the prescribed chemotherapy schedule.

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did not reach statistical significancep = 0.204not close (p > 0.1)

However, among those treated with taxanes ( N = 12), the reduction was only −0.9 (95% CI: −2.4 to 0.6), which did not reach statistical significance ( p = 0.204), whereas among those who underwent oxaliplatin treatment ( N = 29) there was a significant reduction (−1.8; 95% CI: −2.6 to −0.9; p < 0.001).

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