Nitrite increases mitofusin-1 levels to inhibit vascular smooth muscle cell proliferation and prevent intimal hyperplasia.

Additionally, nitrite treated cells showed decreased expression of the cell cycle modulator, cyclin D1, which drives cell cycle entry and G1 phase progression [ 45 ], and a slight decrease in the cell senescence suppressor CDK2 [ 46 ], which did not reach statistical significance ( Fig. 1 C).

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