Eutopic echoes ectopic: organoid-based evidence of shared hormone dysregulation in endometriosis.

Upon E2 stimulation, a highly significant decrease of ESR1 expression in all samples was detected, in EMT by 40.3% (* p = 0.0015), euEMT by 35.7% (** p = 0.0085), and ecEMT by 38.2% (** p = 0.0012) (Fig. 4 A).

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Although the following differences did not reach statistical significance, basal ESR1 expression appeared lower in euEMT and ecEMT compared to EMT, aligning with previous findings and suggesting altered E2 sensitivity in endometriosis-derived tissues [ 5 , 41 ].

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